Ranolazine and Ivabradine - Their Current Use

Chronic stable angina is a debilitating illness affecting millions worldwide. Considerable progress has been made over the last 30 years in the understanding of the pathogenesis of angina pectoris. Over the period, number of pharmacological measures such as nitrates, beta-Blockers, calcium channel blockers and revascularisation strategies such as Coronary Artery Bypass Grafting (CABG) and Coronary Angioplasty have been introduced but still many patients continue to experience Angina despite being on optimal medical therapy. In addition there are a number of patients particularly elderly patients who are unsuitable for revascularisation procedures or they do not tolerate higher doses of conventional anti-anginal drugs. In such cases a novel medical treatment with different mechanism of action would be particularly beneficial in relieving the symptoms. RANOLAZINE AND IVABRADINE THEIR CURRENT USE